Content Expertise

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My 20+ years as a consulting biostatistician encompass numerous areas of clinical medicine. I have developed specific research expertise in neurodevelopmental disorders, such as ASD, ADHD, and OCD, including the analysis of several

 

  • cognitive measures, and

  • rating scales.  

 

I have gained extensive knowledge in cystic fibrosis analyzing data from hospital, national, and international databases across a range of clinical areas:

 

  • lung function,

  • pancreatic function,

  • cystic fibrosis related diabetes,

  • transplant,

  • infection, and

  • diagnostic testing  

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While biostatisticians can analyze data on any subject matter, including areas unrelated to health care, with experience gained from long-term collaborations, biostatisticians become familiar with issues specific to your field: 

 

  • floors and ceilings on laboratory measures,

  • variables with known threshold effects,

  • subgroups of patients whose data are known to deviate from others, and

  • the inter-relationship of variables of interest

 

This content knowledge informs the development of the study design and statistical methods, the interpretation of model results, and the choice of tables and figures that best highlight the final story for a clinical audience. 

Selected manuscripts

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Neurodevelopmental disorders:

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Dupuis A, Indralingam A, Chevrier A, Crosbie C, Arnold P, Burton CL, Schachar R. Response time adjustment in the Stop Signal Task: development in children and adolescents.  Child Dev. 2019 Mar;90(2):e263-e272. doi: 10.1111/cdev.13062. Epub 2018 Mar 30

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Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ, Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Lerch J, Anagnostou E. Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders. Sci Rep. 2017 Sep 14;7(1):11618. doi: 10.1038/s41598-017-10821-0.

 

van der Plas E., Dupuis A., Arnold P., Crosbie J., Schachar R. Association of autism spectrum disorder with obsessive-compulsive and attention-deficit/hyperactivity traits in a community sample. J Autism Dev Disord. 2016 Sep;46(9):3115-25. doi: 10.1007/s10803-016-2853-y.

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Cystic Fibrosis:

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Dupuis A, Keenan K, Ooi CY, Dorfman R, Sontag MK, Naehrlich L, Castellani C, Strug L, Rommens J, Gonska T. Prevalence of Meconium ileus (MIP) marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Genet Med. 2016 Apr;18(4):333-40 doi: 10.1038/gim.2015.79 

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Dupuis A, Hamilton D, Cole DE, Corey M.  Cystic Fibrosis Birth Rates in Canada: A Decreasing Trend since the Onset of Genetic Testing  J Pediatr.  2005 Sep;147(3):312-5. doi:10.1016/j.jpeds.2005.06.043

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Ooi CY, Dupuis A, Gonska T, Ellis L, Ni A, Jarvi K, Martin S, Ray P, Steele L, Kortan P, Dorfman R, Solomon M, Zielenski J, Corey M, Tullis E, Durie P. Does Integration of Different Ion Channel Measurements Improve Diagnostic Performance in Cystic Fibrosis?  Ann Am Thorac Soc. 2014 May;11(4):562-70.

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Ooi CY, Dupuis A, Ellis L, Jarvi K, Martin S, Ray PN, Steele L, Kortan P, Gonska T, Dorfman R, solomon M, Zielenski J, Corey M, Tullis E, Durie P.  Does extensive genotyping and nasal potential difference testing clarify the diagnosis of cystic fibrosis among patients with single-organ manifestations of cystic fibrosis?  Thorax 2014 Mar;69(3):254-60.

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Full list of manuscripts in:

Resume (PDF)